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Folinic acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antifolate (6) Bacterial (1) Endogenous Metabolite (5) Isotope-Labeled Compounds (2) Parasite (2)
By Research Areas:	Cancer (7) Infection (2)

9

Inhibitors & Agonists

5

Natural
Products

2

Isotope-Labeled Compounds

Targets Recommended: Amino Acid Derivatives Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Folinic acid Maximum Cited Publications 9 Publications Verification leucovorin	Antifolate Endogenous Metabolite	Cancer
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

Folinic acid-d4 calcium hydrate Leucovorin-d₄ calcium hydrate	Isotope-Labeled Compounds	Cancer
Folinic acid-d₄-1 (Leucovorin-d₄-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.

Folinic acid calcium Maximum Cited Publications 9 Publications Verification Leucovorin calcium; Calcium folinate	Antifolate Endogenous Metabolite	Cancer
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

Folinic acid disodium Leucovorin disodium	Endogenous Metabolite Antifolate	Cancer
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma .

Folinic acid calcium hydrate Leucovorin calcium hydrate	Antifolate Endogenous Metabolite	Cancer
Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

Folinic acid calcium salt pentahydrate Maximum Cited Publications 9 Publications Verification Leucovorin calcium salt pentahydrate	Antifolate Endogenous Metabolite	Cancer
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-W653912A

Leucovorin-d4 (calcium hydrate), >90%	Isotope-Labeled Compounds	Cancer
Leucovorin-d₄ (Leucovorin-d₄) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

Pyrimethamine 5 Publications Verification Pirimecidan; Pirimetamin; RP 4753	Antifolate Parasite	Infection
Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .

Antileishmanial agent-22	Parasite Bacterial	Infection
Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC₅₀=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC₅₀), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

Folinic acid Maximum Cited Publications 9 Publications Verification leucovorin	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Plants Moraceae Endogenous metabolite Disease Research Fields Cancer Morus alba Linn.	Antifolate Endogenous Metabolite
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

Folinic acid calcium Maximum Cited Publications 9 Publications Verification Leucovorin calcium; Calcium folinate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Antifolate Endogenous Metabolite
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

Folinic acid calcium salt pentahydrate Maximum Cited Publications 9 Publications Verification Leucovorin calcium salt pentahydrate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Antifolate Endogenous Metabolite
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

Folinic acid disodium Leucovorin disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Antifolate
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma .

Folinic acid calcium hydrate Leucovorin calcium hydrate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Antifolate Endogenous Metabolite
Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

Cat. No.	Product Name	Chemical Structure

Folinic acid-d4 calcium hydrate
Folinic acid-d₄-1 (Leucovorin-d₄-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.

HY-W653912A

Leucovorin-d4 (calcium hydrate), >90%
Leucovorin-d₄ (Leucovorin-d₄) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

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